منابع مشابه
Etiology of Congenital Scoliosis
Congenital scoliosis is an abnormal lateral curvature of the spine, resulting from disruption of normal vertebral development. Although there are many types of defects observed in congenital scoliosis, all result from abnormal formation and segmentation of the vertebral precursors, called somites. Developmental studies in animal models have identified many genes regulating somite formation and ...
متن کاملThe etiology of scoliosis.
Twenty years ago the late John Cobb first showed me that scoliosis could be interesting. By the very simplicity of his teaching he changed an obscure, incomprehensible deformity into a disease which has fascinated me ever since. I recall gratefully his ability to make the complex simple. I propose to look at this deformity in all its forms, to name the questions one must ask and answer if its e...
متن کاملEtiology of idiopathic scoliosis: current trends in research.
Current population studies characterize idiopathic scoliosis as a single-gene disorder that follows the patterns of mendelian genetics, including variable penetrance and heterogeneity. The role of melatonin and calmodulin in the development of idiopathic scoliosis is likely secondary, with indirect effects on growth mechanisms. Reported abnormalities of connective tissue, skeletal muscle, plate...
متن کاملA Mechanism for Gene-Environment Interaction in the Etiology of Congenital Scoliosis
Congenital scoliosis, a lateral curvature of the spine caused by vertebral defects, occurs in approximately 1 in 1,000 live births. Here we demonstrate that haploinsufficiency of Notch signaling pathway genes in humans can cause this congenital abnormality. We also show that in a mouse model, the combination of this genetic risk factor with an environmental condition (short-term gestational hyp...
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ژورنال
عنوان ژورنال: The Pedagogical Seminary
سال: 1915
ISSN: 0891-9402
DOI: 10.1080/08919402.1915.10533959